ZeEcoTox

A recommended model for ecotoxicity

Zebrafish. A model for EcoToxicity

As you may know, zebrafish is a powerful predictive model for drug discovery, with broad applications across different industries.

It bridges cell culture assays (cost effective but poor data content) and mammalian models (expensive but high data content) during the preclinical pipeline. In ecotoxicology studies, zebrafish is a recommended model by the European Union Reference Laboratory for Alternatives to Animal Testing (EURL-ECVAM) and it is regulated by the OECD and EPA.

Hence, the use of zebrafish as biosensor for ecotoxicity is a growing component of the environmental hazard assessment of chemicals and environmental samples from most different locations (cities, environment, industries, agriculture).

The advantages of using zebrafish for HTS toxicological screening are multiple:

•Small size, fast life cycle, high number of progeny and optically transparent.

•Samples are administered in their swimming water. Zebrafish is highly permeable and sensitive to surrounding molecules (small amount needed).

•High genetic conservation with human genome (>80%), tissues, organs and physiological processes, including toxic management.

•High predictivity on hazard assessment relevant to effects on humans.

•Strong impact in 3Rs implementation.

Environmental toxicity can be detected with early life-stages small organisms, for that reason we will use zebrafish embryos in toxicology screening, in combination with other standard models (Daphnia Magna and Algae).

We propose a series of toxicology assays to test, in a high-throughput manner, the presence of contaminants.

ZeCUSTOM

Just tell us your biological/pharmacological question and we propose and run the best zebrafish-based scientific methodology and provide reliable results. Rare diseases, gene functions, biological pathways, drug-target interaction, drug accumulations and much more can be developed and studied in zebrafish.

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