Papers

Predicting teratogenicity modes of action in higher vertebrates

Zebrafish teratogenicity predictivity shown here reinforces the possibility of applying powerful mechanistic approaches.

Papers

Disease-associated GRIN protein truncating variants trigger NMDA receptor loss-of-function

The data presented contribute to delineate GRIN PTVs genotype-phenotype association and GRIN variants stratification

Papers

CRISPR Meets Zebrafish: Accelerating the Discovery of New Therapeutic Targets

We propose that zebrafish, with the use of CRISPR/Cas9 tools, could streamline functional genomic processes to bring biologically relevant knowledge on diseases.

Papers

ZeOncoTest: Refining and Automating the Zebrafish Xenograft Model for Drug Discovery in Cancer

It represents a step further for zebrafish larvae xenografts to enter the regulated preclinical drug discovery path.

Papers

Comparison of Zebrafish Larvae and hiPSC Cardiomyocytes for Predicting Drug-Induced Cardiotoxicity in Humans

Our analysis with zebrafish yields similar predictive performance as previous validation meta-studies performed with dogs, the standard regulatory preclinical model.

Papers

Yap/Taz-TEAD activity links mechanical cues to progenitor cell behavior during zebrafish hindbrain segmentation

Functional experiments demonstrated the pivotal role of Yap/Taz-TEAD signaling in maintaining progenitor features in the hindbrain boundary cell population.

Papers

Multiplex Analysis Platform for Endocrine Disruption Prediction Using Zebrafish

Our data confirm zebrafish larvae as a robust experimental model for predicting EDC activity in its three main endocrine axes.

Papers

Next Generation Sequencing and Animal Models Reveal SLC9A3R1 as a New Gene Involved in Human Age-Related Hearing Loss

These data strongly support the role of SLC9A3R1 gene in the pathogenesis of ARHL.

Papers

Impaired Liver Size and Compromised Neurobehavioral Activity are Elicited by Chitosan Nanoparticles in the Zebrafish Embryo Model

Rafael Miñana, Service Manager at ZeClinics, signs this article as a collaborator with Qatar University.

Papers

In silico and in vivo models for Qatari-specific classical homocystinuria as basis for development of novel therapies.

Valeria Di Giacomo, Senior R&D Researcher in ZeClinics, presents a new paper in collaboration with Qatar University.

Papers

Combining Zebrafish and CRISPR/Cas9: Toward a More Efficient Drug Discovery Pipeline

This review will focus on the most recent advances on CRISPR/Cas9 implementation in zebrafish and all their potential uses in biomedical research and drug discovery.

ZeClinics Resveratrol Papers

Alkylated resveratrol prodrugs and metabolites as potential therapeutics for neurodegenerative diseases

The team led by Dr. Morales has synthesized alkylated resveratrol prodrugs to improve antioxidant and anti-inflammatory properties.

Papers

Evolutionary emergence of the rac3b/rfng/sgca regulatory cluster refined mechanisms for hindbrain boundaries formation

A new insight into a crucial system for segregation of neuronal progenitors within the hindbrain.

Valeria_ZeClinics Papers

Valeria Di Giacomo, R&D Scientist at ZeClinics, has just published an impressive review article in FRONTIERS

They explore the benefits of CRISPR/Cas9 to establish innovative zebrafish models to enhance knowledge of the visual cycle.

Papers

Enhancing understanding visual cycle applying crispr/cas9 gene editing zebrafish

They explore the benefits of CRISPR/Cas9 to establish innovative zebrafish models to enhance knowledge of the visual cycle.

Papers

An Attractive Reelin Gradient Establishes Synaptic Lamination in the Vertebrate Visual System

They establish a mechanism that may represent a general principle for neural network assembly in vertebrate species and across different brain areas.