Papers

Predicting teratogenicity modes of action in higher vertebrates

Zebrafish teratogenicity predictivity shown here reinforces the possibility of applying powerful mechanistic approaches.

Papers

Disease-associated GRIN protein truncating variants trigger NMDA receptor loss-of-function

The data presented contribute to delineate GRIN PTVs genotype-phenotype association and GRIN variants stratification

Papers

CRISPR Meets Zebrafish: Accelerating the Discovery of New Therapeutic Targets

We propose that zebrafish, with the use of CRISPR/Cas9 tools, could streamline functional genomic processes to bring biologically relevant knowledge on diseases.

Papers

Comparison of Zebrafish Larvae and hiPSC Cardiomyocytes for Predicting Drug-Induced Cardiotoxicity in Humans

Our analysis with zebrafish yields similar predictive performance as previous validation meta-studies performed with dogs, the standard regulatory preclinical model.

Papers

Yap/Taz-TEAD activity links mechanical cues to progenitor cell behavior during zebrafish hindbrain segmentation

Functional experiments demonstrated the pivotal role of Yap/Taz-TEAD signaling in maintaining progenitor features in the hindbrain boundary cell population.

Papers

Next Generation Sequencing and Animal Models Reveal SLC9A3R1 as a New Gene Involved in Human Age-Related Hearing Loss

These data strongly support the role of SLC9A3R1 gene in the pathogenesis of ARHL.

Papers

In silico and in vivo models for Qatari-specific classical homocystinuria as basis for development of novel therapies.

Valeria Di Giacomo, Senior R&D Researcher in ZeClinics, presents a new paper in collaboration with Qatar University.

ZeClinics Resveratrol Papers

Alkylated resveratrol prodrugs and metabolites as potential therapeutics for neurodegenerative diseases

The team led by Dr. Morales has synthesized alkylated resveratrol prodrugs to improve antioxidant and anti-inflammatory properties.

Valeria_ZeClinics Papers

Valeria Di Giacomo, R&D Scientist at ZeClinics, has just published an impressive review article in FRONTIERS

They explore the benefits of CRISPR/Cas9 to establish innovative zebrafish models to enhance knowledge of the visual cycle.

Papers

Enhancing understanding visual cycle applying crispr/cas9 gene editing zebrafish

They explore the benefits of CRISPR/Cas9 to establish innovative zebrafish models to enhance knowledge of the visual cycle.

Papers

An Attractive Reelin Gradient Establishes Synaptic Lamination in the Vertebrate Visual System

They establish a mechanism that may represent a general principle for neural network assembly in vertebrate species and across different brain areas.

NEURON - Vincenzo Di Donato, R&D Scientist at ZeClinics, has just published an impressive paper Papers

Vincenzo Di Donato, R&D Scientist at ZeClinics, has just published an impressive paper in NEURON

An Attractive Reelin Gradient Establishes Synaptic Lamination in the Vertebrate Visual System.

Papers

Paper published: “ZeGlobalTox: An Innovative Approach to Address Organ Drug Toxicity Using Zebrafish”

Our article "ZeGlobalTox: An Innovative Approach to Address Organ Drug Toxicity Using Zebrafish" has been published in IJMS