POSTERS

The ZeCardio Platform High Throughput Cardiotoxicity Screening with Zebrafish Embryos

The-ZeCardio-Platform-High-Throughput-Cardiotoxicity-Screening-with-Zebrafish-Embryos POSTERS
papers

Comparison of Zebrafish Larvae and hiPSC Cardiomyocytes for Predicting Drug-Induced Cardiotoxicity in Humans

Our analysis with zebrafish yields similar predictive performance as previous validation meta-studies performed with dogs, the standard regulatory preclinical model.

papers

Yap/Taz-TEAD activity links mechanical cues to progenitor cell behavior during zebrafish hindbrain segmentation

Functional experiments demonstrated the pivotal role of Yap/Taz-TEAD signaling in maintaining progenitor features in the hindbrain boundary cell population.

POSTERS

Validating zebrafish for safety drug screening: A comparison of zebrafish and rodent toxicity data.

Validating zebrafish for safety drug screening A comparison of zebrafish and rodent toxicity data POSTERS
GRANTS

ZeNewCardio – Discovering Heart Regeneration Therapies Through Zebrafish

We propose the development of a high-throughput preclinical platform using the zebrafish model to find suitable treatments for heart regeneration after ischemia.

completed
POSTERS

Zebrafish as complimentary model for drug discovery and chemical prioritization

POSTERS
papers

Multiplex Analysis Platform for Endocrine Disruption Prediction Using Zebrafish

We propose the use of a panel of eight gene expression biomarkers in zebrafish larvae for providing a simple, robust, and fast assay to assess endocrine-disrupting potencies for the three main axes.

papers

Loss of the sphingolipid desaturase DEGS1 causes hypomyelinating leukodystrophy

A knockdown approach for disease modeling in zebrafish, followed by a preclinical test with the first-line treatment for multiple sclerosis, fingolimod.

papers

Next Generation Sequencing and Animal Models Reveal SLC9A3R1 as a New Gene Involved in Human Age-Related Hearing Loss

These data strongly support the role of SLC9A3R1 gene in the pathogenesis of ARHL.

papers

Impaired Liver Size and Compromised Neurobehavioral Activity are Elicited by Chitosan Nanoparticles in the Zebrafish Embryo Model

For the first time, we investigate the potential organ-specific (cardiac, hepatic, and neuromuscular) toxicity of chitosan nanoparticles (ChNPs) using the zebrafish embryo model.

GRANTS

InnoTCM – Innovative Ways of Profiling Traditional Chinese Medicinal Herb Extracts Through Zebrafish

The concept of the InnoTCM project is to apply an innovative approach of profiling the TCM herb extracts by using Zebrafish as a model organism in High Throughput Screening (HTS) manner.

completed
papers

In silico and in vivo models for Qatari-specific classical homocystinuria as basis for development of novel therapies.

Valeria Di Giacomo, Senior R&D Researcher in ZeClinics, presents a new paper in collaboration with Qatar University.

GRANTS

CARDIOREG – Biomarkers and lead molecules for heart regeneration therapies

We aim to implement cardiac injury models in zebrafish and to use them to identify genes involved in heart regeneration, with a focus on genes impairing cardiomyocyte dedifferentiation/proliferation.

completed
papers

Combining Zebrafish and CRISPR/Cas9: Toward a More Efficient Drug Discovery Pipeline

We review the most recent advances on CRISPR/Cas9 implementation in zebrafish and all their potential uses in biomedical research and drug discovery.

GRANTS

ZF-Glioma – Generation of transgenic zebrafish expressing human tyrosine kinase mutants as human glioma (brain cancer) models

ZF-Glioma's aim was to model human glioma (brain cancer) in zebrafish to screen for tyrosine kinase inhibitors (TKIs) with the potential to treat this devastating disease.

completed
papers

Enhancing understanding visual cycle applying CRISPR/Cas9 gene editing zebrafish

They explore the benefits of CRISPR/Cas9 to establish innovative zebrafish models to enhance knowledge of the visual cycle.