ongoing

Visualizing Death Inducing Protein Complexes (VIDEC): Advancing Cell Death Research for Health and Safety

The Research network aims to develope tools for visualizing cell death to enhance treatments and identify chemical hazards.

Start – End dates: 01/07/2023- 01/07/2025

Project reference: 872195

Total budget: 1 237 400.00€

Financed by: European Union

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 872195.

Partners:

National University of Ireland Galway, University of Gothenburg, Rijksuniversiteit Groningen, Protoqsar 2000 SL, Zeclinics SL, Norges Miljo-og Biovitenskaplige Universitet, Universite de Geneve, Institut National de la Sante et de la Recherche Medicale, Univerzita Palackeho v Olomouci.

Summary:

Every day billions of cells die in our bodies as part of normal healthy processes. These cell deaths are called “regulated cell deaths” as they occur through the activation of genetically encoded molecular machinery. However, too little or too much cell death is the cause of various diseases and illness caused by exposure to chemicals. Understanding these cell death processes and how they are controlled may lead to new treatments for disease as well as explaining why some chemicals are hazardous.

Regulated cell deaths, as exemplified by apoptosis, necroptosis, and pyroptosis, are induced by the formation of protein complexes. Here, we will develop new molecular tools to visualize the formation of the protein complexes in live cells and tissues and then use these tools to study cell death in normal and disease processes. Our consortium includes cell death experts, bioluminescence experts, zebrafish experts, as well as structural, developmental, molecular, and cell biologists in industry and academia. The proposed research network will provide intersectoral mobility between laboratories expert in complementary skills. This will drive the development of the new tool and enhance the researchers’ career prospects.

The research is of importance to many citizens of the EC; it will contribute to increasing food security by improving aquaculture, enhancing the health of aging populations through the study of degenerative diseases, improving toxicity assessment to better protect citizens from chemical hazards, and enhancing drug development by better identification of adverse effects. Moreover, the assays emerging from the research will be commercialized by the industrial partners in the network, thus supporting economic development within the EU.