completed

ZF-Glioma - Generation of transgenic zebrafish expressing human tyrosine kinase mutants as human glioma (brain cancer) models

ZF-Glioma's aim was to model human glioma (brain cancer) in zebrafish to screen for tyrosine kinase inhibitors (TKIs) with the potential to treat this devastating disease.

Start – End dates: 01/04/18 – 31/03/21

Project reference: Proyectos CDTI de I+D (IDI-20180384)

Total budget: 200,000€

Funding agency: CDTI, Spain

¨Funded by CDTI with support from the Ministry of Science and Innovation; program Proyectos CDTI de I+D, project reference: IDI-20180384¨

Partners: Dr. Reddy´s Institute of Life Sciences, Hyderabad, India

Summary:

The goal of this project is to develop genetically engineered human glioma (brain cancer) models in zebrafish, by generating transgenic zebrafish carrying the human glioma-associated tyrosine kinase genetic alterations EGFR, EGFRvIII, MET, or AXL. The phenotypes and molecular characteristics of the transgenic zebrafish will be identified, and methods for tyrosine kinase inhibitor screening will be established. The generated models and methods for evaluating chemical and biological entities are the expected outcomes of this proposal. These are of significant commercial value due to their application in pharmaceutical and biopharmaceutical evaluation.

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