BY OUR PLATFORMS
BY THERAPEUTIC AREA
BY RESEARCH STAGE
01 April 2018 - 31 March 2021
Start – End dates: 01/04/18 – 31/03/21
Project reference: Proyectos CDTI de I+D (IDI-20180384)
Total budget: 200,000€
Funding agency: CDTI, Spain
Partners: Dr. Reddy´s Institute of Life Sciences, Hyderabad, India
The goal of this project is to develop genetically engineered human glioma (brain cancer) models in zebrafish, by generating transgenic zebrafish carrying the human glioma-associated tyrosine kinase genetic alterations EGFR, EGFRvIII, MET, or AXL. The phenotypes and molecular characteristics of the transgenic zebrafish will be identified, and methods for tyrosine kinase inhibitor screening will be established. The generated models and methods for evaluating chemical and biological entities are the expected outcomes of this proposal. These are of significant commercial value due to their application in pharmaceutical and biopharmaceutical evaluation.
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