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BY THERAPEUTIC AREA
ZeClinics provides preclinical CRO services to evaluate drugs targeting CNS disorders such as epilepsy and Parkinson Disease. Our CNS diseases experts are ready to partner with you at the early stages of drug and target discovery, providing innovative zebrafish in vivo models to shorten your product’s time to market.
ZeClinics' preclinical CNS research team has extensive experience, ranging from genetic manipulation, disease model generation, and phenotype-based drug screening. Zebrafish genetic models are custom-generated for an accurate characterization of the biological function of your gene of interest. Efficacy and safety screenings are conducted in the most efficient and cost-effective manner.
Zebrafish Solutions Facilitating Successful Development of your CNS Therapies
The zebrafish brain is a suitable paradigm for investigating human neurological and neurodegenerative disorders. It allows screening of compounds and genes with potential neuroprotective or neurotoxic effects.
The main advantages of zebrafish for CNS research are:
Rapid neurodevelopment is completed at 120 hours post-fertilization in zebrafish; vs 22 embryonic + 22 postnatal days in rats and 40 weeks in humans.CNS anatomical and functional conservation between zebrafish and humans: i.e. forebrain, midbrain, hindbrain, and spinal cord.Common neurotransmitter system: the main excitatory and inhibitory neurotransmitters, as well as neuromodulators.Zebrafish possess a functional blood-brain barrier similar to humans.
Rapid neurodevelopment is completed at 120 hours post-fertilization in zebrafish; vs 22 embryonic + 22 postnatal days in rats and 40 weeks in humans.
CNS anatomical and functional conservation between zebrafish and humans: i.e. forebrain, midbrain, hindbrain, and spinal cord.
Common neurotransmitter system: the main excitatory and inhibitory neurotransmitters, as well as neuromodulators.
Zebrafish possess a functional blood-brain barrier similar to humans.
Other important advantages of zebrafish for CNS research include:
Our preclinical CNS research services are developed to help you address:
Generation of custom genetic models of neurologic disorders.
In vivo validation of candidate genes in the context of a disease, for druggable target identification.
Efficacy and toxicity evaluation of candidate therapeutic compounds in a disease context.
All these analyzes can be applied to the CNS research field to study different disorders such as epilepsy, Parkinson Disease, GRINpathies, etc., or the study of CNS side effects of compounds.
Pharmacologically-induced larval zebrafish models that reproduce pathologic and behavioral hallmarks of human CNS disorders. They represent an efficient, cost-effective and human-relevant option to study these conditions.
Get the milestone data you need to make important decisions in the early stages of drug discovery. Contact us to learn more about ZeClinics’ preclinical CNS research services and how we can help accelerate your R&D process.
If you want more information about our CNS disease models or have any other questions, please contact our experts.