BY OUR PLATFORMS
BY THERAPEUTIC AREA
BY OUR PLATFORMS
Developmental Toxicity assay is an optimized method for an enhanced prediction and description of teratogenicity. The broad number of phenotypes tested and the accurate quantification of subtle morphometric changes provide an integral teratogenic profile of your chemical candidate.
3Rs-aligned method for high throughput teratology assessment in vivo.
Predictability levels referred to rodents and humans above 80%.Automated platform to process high amounts of larvae.Mathematical-based approach that increases objectivity of verdicts. Evaluation of an extensive panel of phenotypes.Estimation of teratogenic potencies through teratogenic indexes.Good Laboratory Practice (GLP) like studies.
Predictability levels referred to rodents and humans above 80%.
Automated platform to process high amounts of larvae.
Mathematical-based approach that increases objectivity of verdicts.
Evaluation of an extensive panel of phenotypes.
Estimation of teratogenic potencies through teratogenic indexes.
Good Laboratory Practice (GLP) like studies.
Incubation of embryos with 5 different concentrations of the molecule of interest spaced by a constant factor 2 from 0 to 96 hours post fertilization (hpf). Subsequent automated imaging and evaluation of teratogenicity through a validated panel of phenotypes. Finally, the relationship between mortality and teratogenicity is calculated to determine teratogenic potency (teratogenic index).
Determination of the following parameters at 24 and 96 hpf:
Determination of the following parameters at 96 hpf:
If you want more information about our DevToxassay or have any other questions, pleasecontact our experts.