ZeTox

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icon-early-life-stage-toxicity Early-life stage toxicity

Long term toxic effects of the molecule of interest can be predicted from studies performed with animal models at early life-stages.

Method description

Incubation of zebrafish embryos at 5 different logarithmic concentrations of the molecule of interest for 30 days (based on OECD guidelines).  

Readouts

Observation of the following parameters at days 10, 20 and 30:

  • Determination of growth rate in percentage
  • No observed effect concentration (NOEC)
  • Lowest Observable Effect Concentration (LOEC)
  • Lethal Concentration 50 (LC50)
  • Survival
  • General morphological abnormalities
Figure: Zebrafish larvae