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Fish Embryo Acute Test is designed to determine the acute toxicity of chemicals in vivo in just a few days. The use of fish embryos allows high throughput screening while providing similar predictivity to adult fish and reducing animal testing.
It is described in the OECD 236 Guideline as a test required for ecotoxicological regulatory purposes, and it is also useful to assess the safety of compounds in preclinical research.
3Rs-aligned method for fast and high throughput acute toxicity assessment in vivo.
High experimental throughput for chemical safety assessment in vivo.Convenient drug delivery.Cost-efficiency.Highly predictive for acute toxicity effects in humans.Alternative experimental method to reduce animal testing while evaluating toxicity in vivo.Applicable to a wide range of compounds regardless of the mode of action, volatility, solubility, and hydrophobicity.
High experimental throughput for chemical safety assessment in vivo.
Convenient drug delivery.
Highly predictive for acute toxicity effects in humans.
Alternative experimental method to reduce animal testing while evaluating toxicity in vivo.
Applicable to a wide range of compounds regardless of the mode of action, volatility, solubility, and hydrophobicity.
Incubation of embryos with 5 different concentrations of the molecule of interest spaced by a constant factor 10 from 0 to 96 hours post fertilization (hpf). Following the OECD 236 Guideline, a convenient, rapid and inexpensive acute toxicity test has been set up.
Recording of the following four apical observations as indicators of mortality at 24 and 96 hpf:
Concentration-effect curve at 96 hpf to determine the following parameters:
If you want more information about our FET assay or have any other questions, please contact our experts.