ZeEfficacy – Efficacy Services


Hearing Loss Model

The lateral line, an external sensory system, comprises individual sense organs (neuromasts), permitting detection of local water displacements and vibration.
Zebrafish HC neuromast and human inner ear HCs show high degree of morphological, physiological and genetic conservation. The accessibility to the hair cells on the lateral line, and the transparency of the model, facilitates the study of novel compounds’ efficacy.

High conservation permits zebrafish to be a pharmacological model to identify new oto-protectant/oto-regenerative therapeutic drugs.

Method description

Figure: Hearing loss model method description