Hit-to-Lead

Zebrafish is the perfect platform for hit optimization and generation of backups. Quantitative readouts can be analyzed to assess how the chemical modification of substructures can impact on the compound efficacy.

Stable genetic zebrafish lines permit to correlate phenotypic readouts with target binding (see target validation) making zebrafish a robust tool for the optimization of inhibitors, agonists and antagonists, and the generation of their analogs.

Moreover, combining tests from our ZeEfficacy and ZeTox platforms we are able to design tests in which multiple aspects are optimized and improved within the same assay optimizing resources and thus reducing time and costs.


View our Hit-to-Lead services