Ophthalmology Model

Owing to its human-like cone-dominant vision and preserved developmental pathways, zebrafish mirrors human eye pathology better than rodents, while facilitating early developmental studies and single-cell-resolution retinal characterization. As all vertebrates, zebrafish conserves the five main neuronal cell types and one class of glia cells. 

At ZeClinics, we provide the opportunity to study the spatial distribution of these cells, defined as a layer. In specific, we focus our services in the outer nuclear layer (ONL) comprised with rod and cone photoreceptors, where we can evaluate not only the thickness of the layer but also the cell number that is composed with.

This layer is of interest due to the regenerative capacity of the photoreceptors. Therefore, at ZeClinics, we have developed and validated a human-relevant model based on the similar protocols but with opposite treatments. A human-relevant model for dry age-related macular disease studies (Dry-AMD) through light-induced retinal degeneration to identify either preventive or therapeutic treatments.

View our Ophthalmology Model services