Our Model

A model organism that allows obtaining high-quality data in a fast and cost-effective manner

We understand that pre-clinical phase is critical and expensive. In fact,  30% of drug development is taken during this phase. Believe us, we have been there.

Developing new drugs costs you around €500-1,000 bn and takes 10-15 years.

Zebrafish helps both academy and pharmaceutical industry to save time and money obtaining, high-quality data in pre-clinical studies for assessing toxicity and efficacy for new drugs.

More than 40,000 papers published have allowed zebrafish model to become an essential tool for high-throughput screenings of small molecules with therapeutic effects.

Fields of development

All these features have allowed using Zebrafish to yield considerable advances in the fields of infection, cardiovascular diseases, neural disorders or cancer, among other areas such as:

model-developmental-biology Developmental biology
model-oncology Oncology
model-toxicology Toxicology
model-teratology Teratology
model-genetics Genetics
model-neurobiology Neurobiology
model-stem-cell-research Stem cell research
model-regenerative-medicine Regenerative medicine
model-evolutionary-theory Evolutionary theory
model-reproductive-studies Reproductive studies
model-environmental-sciences Environmental sciences
ophthalmology icon Ophthalmology

We stand out as a zebrafish CRO due to the diversity of services that we offer which are led by a scientist team specialized in each field of development

The 5 main advantages you achieve by using zebrafish as a model organism for biomedicine and drug discovery are as follows:
Environment controlled

Drugs are administered directly in their swimming water. 

This feature has two main advantages:

  • First, it saves time whether is compared during the procedure, for instance, with the time invested in injecting drugs in mice. 
  • Second, it helps to understand how a molecule behaves in terms of ADME (Absorption, Distribution, Metabolism, and Excretion) when confronted to a biochemical or cell culture drug screening. Both of them, by nature, will give much limited information in that regard.
Fast life cycle

Zebrafish reproduce 9,000 offspring in a lifetime, compared to only 300 offspring over a mouse's
lifetime. The small size and the high number of the zebrafish progeny allows the parallel and
reproducible testing of several drugs and dosages in simple multiwell plates.

High genetic and physiological homology to humans

Zebrafish and humans have a high genetic homology, as well as high physiological and functional conservation. More than 70% of human genes have a zebrafish orthologue gene. This percentage goes up to 82% if we only consider genes that are associated to human diseases. This fact allows to asses with certainty the possible toxicity or efficacy that a compound could have when administered to us.

Open window

Zebrafish transparency, combined with a growing battery of fluorescent tissue-specific zebrafish transgenic lines, plus novel advances in imaging capture and processing, allows analyzing in vivo the effects of drugs in groups of cells or single tissues.

10X cost-effective HTS

Zebrafish maintenance costs allow us to share with you more wider and fair margins than traditional drug discovery tests. This is because zebrafish are small and social, with 70 individuals per tank, (versus only five mice per cage).