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We understand that pre-clinical phase is critical and expensive. In fact, 30% of drug development is taken during this phase. Believe us, we have been there.
Developing new drugs costs you around €500-1,000 bn and takes 10-15 years.
Zebrafish helps both academy and pharmaceutical industry to save time and money obtaining, high-quality data in pre-clinical studies for assessing toxicity and efficacy for new drugs.
More than 40,000 papers published have allowed zebrafish model to become an essential tool for high-throughput screenings of small molecules with therapeutic effects.
All these features have allowed using Zebrafish to yield considerable advances in the fields of infection, cardiovascular diseases, neural disorders or cancer, among other areas such as:
We stand out as a zebrafish CRO due to the diversity of services that we offer which are led by a scientist team specialized in each field of development
Drugs are administered directly in their swimming water.
This feature has two main advantages:
Zebrafish reproduce 9,000 offspring in a lifetime, compared to only 300 offspring over a mouse'slifetime. The small size and the high number of the zebrafish progeny allows the parallel andreproducible testing of several drugs and dosages in simple multiwell plates.
Zebrafish and humans have a high genetic homology, as well as high physiological and functional conservation. More than 70% of human genes have a zebrafish orthologue gene. This percentage goes up to 82% if we only consider genes that are associated to human diseases. This fact allows to asses with certainty the possible toxicity or efficacy that a compound could have when administered to us.
Zebrafish transparency, combined with a growing battery of fluorescent tissue-specific zebrafish transgenic lines, plus novel advances in imaging capture and processing, allows analyzing in vivo the effects of drugs in groups of cells or single tissues.
Zebrafish maintenance costs allow us to share with you more wider and fair margins than traditional drug discovery tests. This is because zebrafish are small and social, with 70 individuals per tank, (versus only five mice per cage).