Metabolic Disease Models

Zebrafish represents a fantastic model to study metabolic disorders since possess all the organs involved in metabolism such as appetite circuits contained in the hypothalamus, pancreas and also organs sensitive to insulin as muscle, liver and adipose tissue. Moreover, zebrafish share highly conserved metabolic pathways with mammals, with the added value of larger and statistically significant populations.

We have developed a biological-reliable model of atherosclerosis through which ZeClinics is able to enzymatically quantify the cholesterol accumulated and the transparency of zebrafish embryos also facilitate in vivo cholesterol quantification via non-invasive confocal imaging.

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