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ZeClinics provides preclinical in vivo CRO services using innovative zebrafish models of metabolic disorders such as obesity, non-alcoholic fatty liver disease (NAFLD), and atherosclerosis, with the added value of larger and statistically significant populations than classic animal models.
Zebrafish solutions for accelerating metabolic preclinical research.
Our metabolic field experts offer their experience in drug discovery using zebrafish to help you design and run efficient and cost-effective studies to accelerate your R&D process.
Zebrafish represents a fantastic model to study metabolic disorders because of the remarkable genetic, anatomic, and functional similarities with humans in lipid metabolism, adipogenic pathways, pancreas structure, and glucose homeostasis.
Zebrafish share with mammals:
The conservation of a critical human lipoprotein-modifying enzyme (CETP) makes zebrafish prone to dyslipidemia with short dietary interventions, unlike rodents, which are generally resistant to atherosclerosis.
Our preclinical metabolic research services are developed to help you addressing:
Generation of custom genetic models of metabolic disorders.
Use of genetic models to understand gene biological function in a given condition.
Application of zebrafish to efficacy evaluation in drug discovery.
Several studies demonstrated significant metabolic changes can be generated in zebrafish through relatively short dietary interventions. Similar to mammals, excessive nutrients in zebrafish cause increased plasma triglyceride levels and hepatic steatosis. Obese zebrafish also exhibit dysregulation of pathways that control lipid metabolism, including SREBF1, PPARs, NR1H3, and LEP.
ZeClinics' metabolic experts have developed in-house and gold standard nutritional models for metabolic conditions. Our diet-based adult, juvenile, and larval zebrafish models recapitulate the key aspects of metabolic diseases, and represent an efficient, cost-effective, and human-relevant option to study these conditions.
For genetic functional studies of potential obesity-modulating genes.
For genetic functional studies of potential hepatic steatosis-modulating genes.
For genetic functional studies of potential cholesterol-regulatory genes.
Get the milestone data you need to make important decisions in the early stages of drug discovery. Contact us to learn more about ZeClinics’ preclinical metabolic research services and how we can help accelerate your R&D process.