ZeEfficacy

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Parkinson Disease Model

Parkinson Disease (PD) is a neurological disorder characterized by loss of dopaminergic neurons in the brain.
Zebrafish larvae exposed to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) suffer a selective loss of zebrafish dopaminergic neurons, eliciting behavioural symptoms characteristic of PD.

Therefore, zebrafish has become a powerful system to study the molecular events of Parkinson Disease and identify new neuroprotective drugs.

Method description

Evaluation of therapeutic compounds that may prevent dopaminergic neuronal loss and the consequential behavioral alterations caused by the exposure to the neurotoxin MPTP.

Resveratrol, a neuroprotectant effective in murine and zebrafish MPTP-induced PD models, is used as positive experimental control.

MPTP-treated larvae show a strong locomotion activity decrease, in comparison to control siblings.