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ZeGenesis platform is a portfolio of genetic services including but not limited to mutagenesis, transgenesis, and gene expression modulation studies. We are an officially licensed CRISPR solutions provider.
We can generate tailored somatic or germline editing in order to deliver stable genetically-modified zebrafish lines optimized to your requirements. We can also transiently modify gene expression according to your experimental needs.
Our zebrafish genetic services are the solution for the following scientific purposes:
Zebrafish has emerged as an alternative model to in vitro and murine models, in which mutants and transgenics can be more easily generated and phenotypically analyzed. These are some of its advantages:
The generation of stable genetically-modified lines may be required according to your gene editing goals. We can establish and deliver your custom stable mutant or transgenic zebrafish strains carrying germline edits. You can choose from:
These stable lines are the perfect approach for:
We can additionally perform phenotypic characterization of these lines or use them for compound screening.
If your biological question requires the analysis of the effect of gene loss-of-function or gene overexpression at early developmental stages, the generation of stable genetically-modified zebrafish lines may not be required.
In these cases, we offer alternative more rapid approaches, which consist in transiently modifying gene expression. This strategy is also appropriate if you want to evaluate a set of candidate genes in order to discard invalid targets and prioritize the few best.
To this end, we provide you with different solutions:
Phenotypes resulting from gene loss-of-function or gene overexpression can be characterized on demand in the whole organism or in specific organs.