GRANTS

CARDIOMYO – An integrated HTS platform for the discovery of new therapeutics against cardiomyopathies

CARDIOMYO combines three complementary approaches: 1) high content phenotypic in vitro cardiac assays 2) a novel in vivo cardiovascular phenotyping using zebrafish and 3) drug discovery chemistry

ongoing
GRANTS

NanoDIRE-CT – Use of nanobodies for targeted therapy against tumor stem cells

Our purpose is to isolate nanobodies that bind cancer stemm cells and have a direct cytotoxic effect on them, or could act as carriers of cytotoxic drugs specifically towards them.

ongoing
GRANTS

SCilS – Studying Ciliary Signaling in Development and Disease

SCilS is training a new generation of scientists to characterise ciliopathies, an increasingly important and diverse class of inherited diseases.

ongoing
GRANTS

REANIMA – New-generation cardiac therapeutic strategies directed to the activation of endogenous regenerative mechanisms

REANIMA aims to deliver new therapies for heart regeneration, thereby reverting the conditions that lead to heart failure.

ongoing
GRANTS

ZENITH – ZEbrafish Neuroscience Interdisciplinary Training Hub

The EU-funded ZENITH project is preparing a new generation of scientists for interdisciplinary collaboration on pressing neuroscience challenges utilising the zebrafish model system.

ongoing
GRANTS

ZeNewCardio – Discovering Heart Regeneration Therapies Through Zebrafish

We propose the development of a high-throughput preclinical platform using the zebrafish model to find suitable treatments for heart regeneration after ischemia.

completed
GRANTS

InnoTCM – Innovative Ways of Profiling Traditional Chinese Medicinal Herb Extracts Through Zebrafish

The concept of the InnoTCM project is to apply an innovative approach of profiling the TCM herb extracts by using Zebrafish as a model organism in High Throughput Screening (HTS) manner.

completed
GRANTS

CARDIOREG – Biomarkers and lead molecules for heart regeneration therapies

We aim to implement cardiac injury models in zebrafish and to use them to identify genes involved in heart regeneration, with a focus on genes impairing cardiomyocyte dedifferentiation/proliferation.

completed
GRANTS

ZF-Glioma – Generation of transgenic zebrafish expressing human tyrosine kinase mutants as human glioma (brain cancer) models

ZF-Glioma's aim was to model human glioma (brain cancer) in zebrafish to screen for tyrosine kinase inhibitors (TKIs) with the potential to treat this devastating disease.

completed
GRANTS

ZeCardio – Cardiotoxicity High-throughput screening (HTS) with zebrafish embryo

Within this project ZeClinics developed ZeCardio®, a unique, fully automated, robotic and software-driven cardiovascular screening platform.

completed
GRANTS

ZePharma – Process development and automation for the preclinical phase of new drug discovery

The objective of the project is to analyze libraries of molecules provided by collaborating entities with a view to discovering molecules with cardioprotective and anti-tumor therapeutic actions.

completed
GRANTS

STEM ZeOncoTest – Diagnostic method to assess the effectiveness of antitumor drugs

The STEM-ZeOncoTest is an innovative and versatile product for oncological diagnosis that offers a quick and economical solution for making decisions about the treatment of therapy.

completed
GRANTS

ZeGlobalTox – multi-organ toxicity testing in zebrafish

ZeGlobalTox is an innovative safety test able to reduce the number of used animals, experimental time and R&D costs during drug discovery.

completed