Science | ZeClinics®

31 August 2023

Toward the Use of Novel Alternative Methods in Epilepsy Modeling and Drug Discovery

We explore animal alternatives, particularly zebrafish larval models, along with advanced Crispr/Cas9 techniques, streamlining epilepsy modeling and antiepileptic drug trials.

GRANTS

01 December 2022 - 30 November 2025

ZeNeuroid: Human-based Neural Organoid Network for Drug Discovery

The project will use patient derived-iPSC and CRISPR-edited human IPSC to develop a novel three-dimensional microfluidic system for drug discovery.

ongoing

POSTERS

15 November 2022

Increasing predictivity of compound multi-organ toxicity through high-throughput zebrafish assays

POSTERS

03 October 2022

A novel platform for unraveling the role of the primary cilium in heart regeneration

POSTERS

GRANTS

01 October 2022 - 30 September 2027

EdiGenT – New Prime Editing and non-viral delivery strategies for Gene Therapy

The EdiGenT consortium will work to develop a new generation of more efficient gene correction tools based on the CRISPR/Cas9 system, and non-viral delivery strategies for gene therapy.

ongoing

POSTERS

17 September 2022

Zebrafish, a novel key player for human risk assessment: latest advances on developmental neurotoxicity from an international consortium.

POSTERS

16 September 2022

Zebrafish-based high throughput platform for human developmental toxicity assessment

POSTERS

09 May 2022

A novel medium-throughput platform for target validation of regulators of cardiac regeneration in zebrafish larvae

POSTERS

papers

11 March 2022

Implementation of Zebrafish Ontologies for Toxicology Screening

The NTP’s SEAZIT undertook a collaborative exercise to evaluate how the application of standardized phenotype terminology improved data consistency.

papers

07 March 2022

Intravitreal Administration of rhNGF Enhances Regenerative Processes in a Zebrafish Model of Retinal Degeneration

We demonstrate the highly conserved nature of NGF canonical pathway in zebrafish and thus support the use of zebrafish models for testing new compounds with potential retinal regenerative properties.

GRANTS

01 January 2022 - 30 June 2023

ZeBYTE – Platform to predict the effect of drugs based on the use of zebrafish and artificial intelligence

ZeBYTE aims at using artificial intelligence technologies along the whole target discovery process.

ongoing

POSTERS

18 October 2021

Unraveling the role of the primary cilium in heart regeneration

POSTERS

GRANTS

01 August 2021 - 01 August 2023

REMODEL – pREcise gene delivery for advanced disease MODELing

A cutting-edge gene-editing platform to generate complex disease models to test innovative therapeutic approaches.

ongoing

POSTERS

16 June 2021

High-throughput and integrative approaches for quality control of Cas9 variants

POSTERS

GRANTS

01 April 2021 - 31 March 2024

ROBO-FISH – Automated high-throughput oncology drug screening in zebrafish using robotics and AI

The ROBO-FISH consortium will develop and validate injection and imaging robots to automate oncology drug screening in zebrafish to mimic human disease.

ongoing

POSTERS

12 March 2021

Morphometric analysis in zebrafish embryos to predict teratogenicity and modes of action in mammals

POSTERS

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