POSTERS

Unraveling the role of the primary cilium in heart regeneration

poster_katerina POSTERS
POSTERS

High-throughput and integrative approaches for quality control of Cas9 variants

Poster-IZFC-2021 POSTERS
GRANTS

ROBO-FISH – Automated high-throughput oncology drug screening in zebrafish using robotics and AI

The ROBO-FISH consortium will develop and validate injection and imaging robots to automate oncology drug screening in zebrafish to mimic human disease.

ongoing
POSTERS

Morphometric analysis in zebrafish embryos to predict teratogenicity and modes of action in mammals

Zeclinics-Poster-SOT2021 POSTERS
POSTERS

ZeGenesis: an innovative CRISPR/Cas9-based platform to boost target and drug discovery in zebrafish

poster_SLAS_FDS POSTERS
GRANTS

CARDIOMYO – An integrated HTS platform for the discovery of new therapeutics against cardiomyopathies

CARDIOMYO combines three complementary approaches: 1) high content phenotypic in vitro cardiac assays 2) a novel in vivo cardiovascular phenotyping using zebrafish and 3) drug discovery chemistry

ongoing
papers

Morphometric analysis of developing zebrafish embryos allows predicting teratogenicity modes of action in higher vertebrates

Zebrafish teratogenicity predictivity shown here reinforces the possibility of applying powerful mechanistic approaches.

papers

Disease-associated GRIN protein truncating variants trigger NMDA receptor loss-of-function

The data presented contribute to delineate GRIN PTVs genotype-phenotype association and GRIN variants stratification

GRANTS

NanoDIRE-CT – Use of nanobodies for targeted therapy against tumor stem cells

Our purpose is to isolate nanobodies that bind cancer stemm cells and have a direct cytotoxic effect on them, or could act as carriers of cytotoxic drugs specifically towards them.

ongoing
papers

CRISPR Meets Zebrafish: Accelerating the Discovery of New Therapeutic Targets

We propose that zebrafish, with the use of CRISPR/Cas9 tools, could streamline functional genomic processes to bring biologically relevant knowledge on diseases.

papers

“Safe” Chitosan/Zinc Oxide Nanocomposite Has Minimal Organ-Specific Toxicity in Early Stages of Zebrafish Development.

Zebrafish has become one of the most employed models for ecotoxicology studies. Here we evaluate potential toxic effects of a new promising "green" biocide using zebrafish embryos.

GRANTS

SCilS – Studying Ciliary Signaling in Development and Disease

SCilS is training a new generation of scientists to characterise ciliopathies, an increasingly important and diverse class of inherited diseases.

ongoing
GRANTS

REANIMA – New-generation cardiac therapeutic strategies directed to the activation of endogenous regenerative mechanisms

REANIMA aims to deliver new therapies for heart regeneration, thereby reverting the conditions that lead to heart failure.

ongoing
papers

ZeOncoTest: Refining and Automating the Zebrafish Xenograft Model for Drug Discovery in Cancer

The aim of our work was to standardize, automate, and validate a zebrafish larvae xenograft assay with increased translatability and higher drug screening throughput.

GRANTS

ZENITH – ZEbrafish Neuroscience Interdisciplinary Training Hub

The EU-funded ZENITH project is preparing a new generation of scientists for interdisciplinary collaboration on pressing neuroscience challenges utilising the zebrafish model system.

ongoing
POSTERS

A zebrafish screening platform for genetic association studies in cardiovascular disease

A-zebrafish-screening-platform-for-genetic-association-studies-in-cardiovascular-disease POSTERS