GRANTS

CARDIOMYO – An integrated HTS platform for the discovery of new therapeutics against cardiomyopathies

CARDIOMYO combines three complementary approaches: 1) high content phenotypic in vitro cardiac assays 2) a novel in vivo cardiovascular phenotyping using zebrafish and 3) drug discovery chemistry

ongoing
Papers

Predicting teratogenicity modes of action in higher vertebrates

Zebrafish teratogenicity predictivity shown here reinforces the possibility of applying powerful mechanistic approaches.

Papers

Disease-associated GRIN protein truncating variants trigger NMDA receptor loss-of-function

The data presented contribute to delineate GRIN PTVs genotype-phenotype association and GRIN variants stratification

GRANTS

NanoDIRE-CT – Use of nanobodies for targeted therapy against tumor stem cells

Our purpose is to isolate nanobodies that bind cancer stemm cells and have a direct cytotoxic effect on them, or could act as carriers of cytotoxic drugs specifically towards them.

ongoing
Papers

CRISPR Meets Zebrafish: Accelerating the Discovery of New Therapeutic Targets

We propose that zebrafish, with the use of CRISPR/Cas9 tools, could streamline functional genomic processes to bring biologically relevant knowledge on diseases.

GRANTS

REANIMA – New-generation cardiac therapeutic strategies directed to the activation of endogenous regenerative mechanisms

REANIMA aims to deliver new therapies for heart regeneration, thereby reverting the conditions that lead to heart failure.

ongoing
GRANTS

SCilS – Studying Ciliary Signaling in Development and Disease

SCilS is training a new generation of scientists to characterise ciliopathies, an increasingly important and diverse class of inherited diseases.

ongoing
GRANTS

ZENITH – ZEbrafish Neuroscience Interdisciplinary Training Hub

The EU-funded ZENITH project is preparing a new generation of scientists for interdisciplinary collaboration on pressing neuroscience challenges utilising the zebrafish model system.

ongoing
posters

A zebrafish screening platform for genetic association studies in cardiovascular disease

Poster
posters

The ZeCardio Platform High Throughput Cardiotoxicity Screening with Zebrafish Embryos

Poster
Papers

Comparison of Zebrafish Larvae and hiPSC Cardiomyocytes for Predicting Drug-Induced Cardiotoxicity in Humans

Our analysis with zebrafish yields similar predictive performance as previous validation meta-studies performed with dogs, the standard regulatory preclinical model.

Papers

Yap/Taz-TEAD activity links mechanical cues to progenitor cell behavior during zebrafish hindbrain segmentation

Functional experiments demonstrated the pivotal role of Yap/Taz-TEAD signaling in maintaining progenitor features in the hindbrain boundary cell population.

posters

Validating zebrafish for safety drug screening ZeClinics

Poster
GRANTS

ZeNewCardio – Discovering Heart Regeneration Therapies Through Zebrafish

We propose the development of a high-throughput preclinical platform using the zebrafish model to find suitable treatments for heart regeneration after ischemia.

completed
posters

Zebrafish as complimentary model ZeClinics

Poster
Papers

Next Generation Sequencing and Animal Models Reveal SLC9A3R1 as a New Gene Involved in Human Age-Related Hearing Loss

These data strongly support the role of SLC9A3R1 gene in the pathogenesis of ARHL.