ZeTox – Toxicology Services

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A safety prediction pipeline

ZeTox service portfolio includes a high-throughput, translatable battery of toxicology assays that uses zebrafish at different developmental stages for the safety assessment of novel drugs and chemicals with a potential risk to humans.

Human toxicity can be predicted from studies with early life-stage animals. The zebrafish model has proven valuable for predicting chemical substance toxicity, both in drug discovery and ecotoxicology sectors, due to its particular features:

  • Small size
  • Large progenies
  • Rapid development
  • Optical transparency
  • Ease to manipulate
  • High genetic homology with humans (>70% of human disease-causing genes)
  • High structural and functional mechanisms conservation with mammals

Every molecule safety study will be initiated by testing its acute toxicology, to determine lethal concentration 50 (LC50) and the ability of the molecule to produce lethal phenotypes. Potential teratogenic effects of the compound during embryonic development can also be assessed (DevTox), as well as sub-lethal effects observed in juvenile life-stage zebrafish (Early-life stage toxicity).

To further characterize the general safety profile of the molecule, we can test its potential organ-specific toxicity: liver (HepatoTox), heart (CardioTox), central nervous system (NeuroTox), and hearing system (OtoTox). We also offer a combined option to analyze cardio-, neuro-, and hepatotoxicity into a single sequential procedure (ZeGlobalTox). Chemicals can also be interrogated about their potential impact on animal reproduction (ReproductionTox) and endocrine disruption; being both aspects of great relevance for the environmental toxicology field.