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papers

31 August 2023

Toward the Use of Novel Alternative Methods in Epilepsy Modeling and Drug Discovery

We explore animal alternatives, particularly zebrafish larval models, along with advanced Crispr/Cas9 techniques, streamlining epilepsy modeling and antiepileptic drug trials.

papers

11 March 2022

Implementation of Zebrafish Ontologies for Toxicology Screening

The NTP’s SEAZIT undertook a collaborative exercise to evaluate how the application of standardized phenotype terminology improved data consistency.

papers

07 March 2022

Intravitreal Administration of rhNGF Enhances Regenerative Processes in a Zebrafish Model of Retinal Degeneration

We demonstrate the highly conserved nature of NGF canonical pathway in zebrafish and thus support the use of zebrafish models for testing new compounds with potential retinal regenerative properties.

papers

23 November 2020

Morphometric analysis of developing zebrafish embryos allows predicting teratogenicity modes of action in higher vertebrates

Zebrafish teratogenicity predictivity shown here reinforces the possibility of applying powerful mechanistic approaches.

papers

10 October 2020

Disease-associated GRIN protein truncating variants trigger NMDA receptor loss-of-function

The data presented contribute to delineate GRIN PTVs genotype-phenotype association and GRIN variants stratification

papers

28 May 2020

CRISPR Meets Zebrafish: Accelerating the Discovery of New Therapeutic Targets

We propose that zebrafish, with the use of CRISPR/Cas9 tools, could streamline functional genomic processes to bring biologically relevant knowledge on diseases.

papers

13 January 2020

“Safe” Chitosan/Zinc Oxide Nanocomposite Has Minimal Organ-Specific Toxicity in Early Stages of Zebrafish Development.

Zebrafish has become one of the most employed models for ecotoxicology studies. Here we evaluate potential toxic effects of a new promising "green" biocide using zebrafish embryos.

papers

24 December 2019

ZeOncoTest: Refining and Automating the Zebrafish Xenograft Model for Drug Discovery in Cancer

The aim of our work was to standardize, automate, and validate a zebrafish larvae xenograft assay with increased translatability and higher drug screening throughput.

papers

05 August 2019

Comparison of Zebrafish Larvae and hiPSC Cardiomyocytes for Predicting Drug-Induced Cardiotoxicity in Humans

Our analysis with zebrafish yields similar predictive performance as previous validation meta-studies performed with dogs, the standard regulatory preclinical model.

papers

04 July 2019

Yap/Taz-TEAD activity links mechanical cues to progenitor cell behavior during zebrafish hindbrain segmentation

Functional experiments demonstrated the pivotal role of Yap/Taz-TEAD signaling in maintaining progenitor features in the hindbrain boundary cell population.

papers

08 April 2019

Multiplex Analysis Platform for Endocrine Disruption Prediction Using Zebrafish

We propose the use of a panel of eight gene expression biomarkers in zebrafish larvae for providing a simple, robust, and fast assay to assess endocrine-disrupting potencies for the three main axes.

papers

01 March 2019

Loss of the sphingolipid desaturase DEGS1 causes hypomyelinating leukodystrophy

A knockdown approach for disease modeling in zebrafish, followed by a preclinical test with the first-line treatment for multiple sclerosis, fingolimod.

papers

26 February 2019

Next Generation Sequencing and Animal Models Reveal SLC9A3R1 as a New Gene Involved in Human Age-Related Hearing Loss

These data strongly support the role of SLC9A3R1 gene in the pathogenesis of ARHL.

papers

19 January 2019

Impaired Liver Size and Compromised Neurobehavioral Activity are Elicited by Chitosan Nanoparticles in the Zebrafish Embryo Model

For the first time, we investigate the potential organ-specific (cardiac, hepatic, and neuromuscular) toxicity of chitosan nanoparticles (ChNPs) using the zebrafish embryo model.

papers

26 November 2018

In silico and in vivo models for Qatari-specific classical homocystinuria as basis for development of novel therapies.

Valeria Di Giacomo, Senior R&D Researcher in ZeClinics, presents a new paper in collaboration with Qatar University.

papers

03 July 2018

Combining Zebrafish and CRISPR/Cas9: Toward a More Efficient Drug Discovery Pipeline

We review the most recent advances on CRISPR/Cas9 implementation in zebrafish and all their potential uses in biomedical research and drug discovery.