papers

Morphometric analysis of developing zebrafish embryos allows predicting teratogenicity modes of action in higher vertebrates

Zebrafish teratogenicity predictivity shown here reinforces the possibility of applying powerful mechanistic approaches.

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Disease-associated GRIN protein truncating variants trigger NMDA receptor loss-of-function

The data presented contribute to delineate GRIN PTVs genotype-phenotype association and GRIN variants stratification

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CRISPR Meets Zebrafish: Accelerating the Discovery of New Therapeutic Targets

We propose that zebrafish, with the use of CRISPR/Cas9 tools, could streamline functional genomic processes to bring biologically relevant knowledge on diseases.

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“Safe” Chitosan/Zinc Oxide Nanocomposite Has Minimal Organ-Specific Toxicity in Early Stages of Zebrafish Development.

Zebrafish has become one of the most employed models for ecotoxicology studies. Here we evaluate potential toxic effects of a new promising "green" biocide using zebrafish embryos.

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ZeOncoTest: Refining and Automating the Zebrafish Xenograft Model for Drug Discovery in Cancer

The aim of our work was to standardize, automate, and validate a zebrafish larvae xenograft assay with increased translatability and higher drug screening throughput.

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Comparison of Zebrafish Larvae and hiPSC Cardiomyocytes for Predicting Drug-Induced Cardiotoxicity in Humans

Our analysis with zebrafish yields similar predictive performance as previous validation meta-studies performed with dogs, the standard regulatory preclinical model.

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Yap/Taz-TEAD activity links mechanical cues to progenitor cell behavior during zebrafish hindbrain segmentation

Functional experiments demonstrated the pivotal role of Yap/Taz-TEAD signaling in maintaining progenitor features in the hindbrain boundary cell population.

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Multiplex Analysis Platform for Endocrine Disruption Prediction Using Zebrafish

We propose the use of a panel of eight gene expression biomarkers in zebrafish larvae for providing a simple, robust, and fast assay to assess endocrine-disrupting potencies for the three main axes.

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Loss of the sphingolipid desaturase DEGS1 causes hypomyelinating leukodystrophy

A knockdown approach for disease modeling in zebrafish, followed by a preclinical test with the first-line treatment for multiple sclerosis, fingolimod.

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Next Generation Sequencing and Animal Models Reveal SLC9A3R1 as a New Gene Involved in Human Age-Related Hearing Loss

These data strongly support the role of SLC9A3R1 gene in the pathogenesis of ARHL.

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Impaired Liver Size and Compromised Neurobehavioral Activity are Elicited by Chitosan Nanoparticles in the Zebrafish Embryo Model

For the first time, we investigate the potential organ-specific (cardiac, hepatic, and neuromuscular) toxicity of chitosan nanoparticles (ChNPs) using the zebrafish embryo model.

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In silico and in vivo models for Qatari-specific classical homocystinuria as basis for development of novel therapies.

Valeria Di Giacomo, Senior R&D Researcher in ZeClinics, presents a new paper in collaboration with Qatar University.

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Combining Zebrafish and CRISPR/Cas9: Toward a More Efficient Drug Discovery Pipeline

We review the most recent advances on CRISPR/Cas9 implementation in zebrafish and all their potential uses in biomedical research and drug discovery.

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Enhancing understanding visual cycle applying CRISPR/Cas9 gene editing zebrafish

They explore the benefits of CRISPR/Cas9 to establish innovative zebrafish models to enhance knowledge of the visual cycle.

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An Attractive Reelin Gradient Establishes Synaptic Lamination in the Vertebrate Visual System

They establish a mechanism that may represent a general principle for neural network assembly in vertebrate species and across different brain areas.

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ZeGlobalTox: An Innovative Approach to Address Organ Drug Toxicity Using Zebrafish

ZeGlobalTox is an innovative assay that sequentially integrates in vivo cardio-, neuro-, and hepatotoxicity assessment in the same animal, thus impacting strongly in the 3Rs principles.