BY OUR PLATFORMS
BY THERAPEUTIC AREA
31 August 2023
We explore animal alternatives, particularly zebrafish larval models, along with advanced Crispr/Cas9 techniques, streamlining epilepsy modeling and antiepileptic drug trials.
11 March 2022
The NTP’s SEAZIT undertook a collaborative exercise to evaluate how the application of standardized phenotype terminology improved data consistency.
07 March 2022
We demonstrate the highly conserved nature of NGF canonical pathway in zebrafish and thus support the use of zebrafish models for testing new compounds with potential retinal regenerative properties.
23 November 2020
Zebrafish teratogenicity predictivity shown here reinforces the possibility of applying powerful mechanistic approaches.
10 October 2020
The data presented contribute to delineate GRIN PTVs genotype-phenotype association and GRIN variants stratification
28 May 2020
We propose that zebrafish, with the use of CRISPR/Cas9 tools, could streamline functional genomic processes to bring biologically relevant knowledge on diseases.
13 January 2020
Zebrafish has become one of the most employed models for ecotoxicology studies. Here we evaluate potential toxic effects of a new promising "green" biocide using zebrafish embryos.
24 December 2019
The aim of our work was to standardize, automate, and validate a zebrafish larvae xenograft assay with increased translatability and higher drug screening throughput.
05 August 2019
Our analysis with zebrafish yields similar predictive performance as previous validation meta-studies performed with dogs, the standard regulatory preclinical model.
04 July 2019
Functional experiments demonstrated the pivotal role of Yap/Taz-TEAD signaling in maintaining progenitor features in the hindbrain boundary cell population.
08 April 2019
We propose the use of a panel of eight gene expression biomarkers in zebrafish larvae for providing a simple, robust, and fast assay to assess endocrine-disrupting potencies for the three main axes.
01 March 2019
A knockdown approach for disease modeling in zebrafish, followed by a preclinical test with the first-line treatment for multiple sclerosis, fingolimod.
26 February 2019
These data strongly support the role of SLC9A3R1 gene in the pathogenesis of ARHL.
19 January 2019
For the first time, we investigate the potential organ-specific (cardiac, hepatic, and neuromuscular) toxicity of chitosan nanoparticles (ChNPs) using the zebrafish embryo model.
26 November 2018
Valeria Di Giacomo, Senior R&D Researcher in ZeClinics, presents a new paper in collaboration with Qatar University.
03 July 2018
We review the most recent advances on CRISPR/Cas9 implementation in zebrafish and all their potential uses in biomedical research and drug discovery.
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