ongoing

ROBO-FISH - Automated high-throughput oncology drug screening in zebrafish using robotics and AI

The ROBO-FISH consortium will develop and validate injection and imaging robots to automate oncology drug screening in zebrafish to mimic human disease.

Start – End dates: 01/04/21 – 31/03/24

Project reference: E!114899

Total budget: 3.349.547,88€

Co-financed by: Eurostars, Eureka EU & CDTI, Spain

¨This project has received funding from the Eurostars-2 joint programme with co-funding from CDTI and the European Union Horizon 2020 research and innovation programme.¨

Partners: Life Science Methods (Países Bajos), Confocal.nl (Países Bajos), Bioreperia (Suecia), Center for Molecular Medicine Norway (Norway)

confocal.nl
center for molecular medicine norway

Summary:

Over 10.000 compounds are screened for each approaved drug as it is still very difficult to predict the safety and efficacy of a drug candidate early in the drug discovery process. Zebrafish zenograft models are a promisisng solution, because they are small, inexpensive to keep and larvae are easy to manipualte and transparent, enabling screening of compunds on human tumours in context of a living organism. However, uptake is limited due to labour intensive workflows.

The ROBO-FISH consortium will develop and validate injection and imaging robots to automate oncology drug screening in zebrafish to mimic human disease. The robots will optimize sample handling and automate organ-specific injection and imaging, enabling high-throughput drug screening with zebrafish larvae. After the project, the validated ROBO-FISH workflow (injection robot and imaging robot) will be implemented at the Centre for Molecular Medicine Norway and CROs ZeClinics and BioReperia.

Did you find this article interesting?
Let us know your opinion about it

Leave a Reply

Your email address will not be published. Required fields are marked *