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In this post we will talk about how genes direct the production of proteins. The flow of information from DNA to RNA to proteins is one of the fundamental principles of molecular biology. It is so important that it is usually called the “central dogma".
The DNA (Deoxyribonucleic acid) is the molecule in which all organisms store their genetic information. Think of DNA as the instructions manual for an organism. It can be found in the nucleus of all cells of an organism, compacted into structures known as chromosomes.
It is a polymer composed by two complementary chains of monomeric units (nucleotides) that form a double helix. Four types of nucleotides can be found in a DNA sequence: Adenine (A), Thymine (T), Cytosine (C), Guanine (G).
The information carried by DNA molecules is organized in different blocks known as genes. A gene is a portion of DNA that represents the basic unit of biological inheritance (the process that allows the passing of a trait from parents to offspring).
The duties specified in the genetic information are performed by proteins.
Proteins are polymeric macromolecules responsible for a vast array of functions, including catalyzing metabolic reactions, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another.
Proteins are composed by a linear chain of amino acids (whose sequence is defined by the nucleotide sequence of the corresponding gene). 20 different amino acids have been described in the sequence of proteins. The various structures and conformation formed by amino acids and proteins are given specific terms.
The primary structure refers to the linear amino acid sequence.
The secondary structure refers to the formation of regular substructures such as alpha helices or beta sheets.
The tertiary structure describes the 3D structure of the protein, accounting for the way the substructures interact with each other.
Finally, if a protein is comprised of multiple polypeptides, their interaction is described in the quaternary structure.
To be transferred from genes to proteins, the genetic information is transmitted to an intermediary molecule: the RNA (Ribonucleic acid).
The RNA is a polymer composed by a single chain of nucleotides. Four types of nucleotides can be found in a RNA sequence: Adenine (A), Uracil (U), Cytosine (C), Guanine (G).
Three types of RNA are necessary to synthetize a protein:
This flow can be simplified as following:
Miriam is a Human Biologist expert in neuropharmacology. After a master’s degree in Pharmaceutical and Biotech Industry, she obtained her PhD in Biomedicine from Pompeu Fabra University (Barcelona). During her doctorate, she focused her research on the behavioral analysis of animal models for neurophenotypical characterization. Since then, she has been working in the healthcare marketing and publicity sector, where she has contributed to developing marketing campaigns for several pharmaceutical brands. In 2021, she joined ZeClinics with a branding and marketing strategy focus.