What Is Nephrotoxicity and Why Drug-Induced Kidney Damage Goes Undetected Nephrotoxicity refers to kidney damage caused by exposure to chemical substances, including therapeutic drugs. The kidneys are particularly vulnerable because their role in filtering, concentrating, and excreting xenobiotics exposes tubular cells to high local concentrations of potentially toxic substances. Drug-induced nephrotoxicity causes approximately 20% of […]

DILI is a top cause of drug failure. Zebrafish hepatotoxicity assays detect liver toxicity earlier and more accurately than traditional preclinical models.

Zebrafish subchronic toxicity testing meets REACH requirements. Early-life stage fish studies deliver growth, reproduction and organ-level data — with lower costs and animal use.

Each year, tens of thousands of fish and other aquatic vertebrates are used in regulatory ecotoxicity studies across Europe alone. As scientific advances and regulatory pressure converge to reduce animal use in chemical safety testing, the industry is undergoing a directional shift to progressively expand the use of new approach methodologies (NAMs). The Need for […]

Zebrafish toxicity screening helps accelerate drug discovery with early safety insights. Explore 3 fast, cost-effective strategies to de-risk compounds.

Learn how zebrafish revolutionize pharmaceutical toxicology by enabling high-throughput environmental and human risk assessments.

Learn about environmental risk assessment (ERA) for medicinal products, including PBT/vPvB evaluations and the role of zebrafish in them.

Developmental toxicity screening using zebrafish offers a predictive, ethical, and cost-effective in vivo model aligned with ICH S5 (R3) standards.

Reproductive toxicity testing with zebrafish provides fast, predictive insights for early-stage drug development aligned with ICH guidelines.

Explore non-clinical safety assessments for new drugs, from ICH guidelines to zebrafish models in preclinical toxicology.

Combining a zebrafish-based high throughput platform with artificial intelligence for human developmental toxicity assessment.

Zebrafish for regulatory purposes in ecotoxicology and safety pharmacology

New trends and updated availability for zebrafish studies in EU and US

Use of biomarkers in endocrine disruption compounds screening and testing with zebrafish

In ZeClinics we bet on emerging technologies to scale our solutions.

From challenge to knowledge: the outstanding performance of zebrafish in predicting toxicity.

ZeClinics laboratory R&D efforts are mainly divided in the development of three research platforms including a number of research areas.